| Age Spots and Hyperpigmentation Clinical Trials | International Research Services, Inc. (IRSI) | Uneven skin tone and increased pigmentation are common changes associated with skin as it ages. Discolorations are a concern for all skin tones, and as the market responds with innovative treatments to combat this damage, IRSI conducts studies which help ...view more Uneven skin tone and increased pigmentation are common changes associated with skin as it ages. Discolorations are a concern for all skin tones, and as the market responds with innovative treatments to combat this damage, IRSI conducts studies which help to prove the safety and efficacy of the products entering the market. view less | ||
| Analytics Laboratory | Buhler Grinding & Dispersing Technologies | The Analytics Laboratory offers a broad range of analyses for innovative processes. For more information about this service, please utilize the "Sales & Technical Support" request link above. | ||
| Anti-sebum Clinical Trials | International Research Services, Inc. (IRSI) | The development of cosmetics to contain the production of sebum and oil is essential and many products are found on a large scale in the market. Clinical tests for anti-sebum / oil control are performed to assess the effect and efficacy of cosmetic produc...view more The development of cosmetics to contain the production of sebum and oil is essential and many products are found on a large scale in the market. Clinical tests for anti-sebum / oil control are performed to assess the effect and efficacy of cosmetic products on the level of sebum secretion. Claims evaluated: dermatologically tested, clinically proven, helps to remove oil/shine, dirt and dead cells, controls oil/shine/oil control/tallow for 24 hours, Our team of experts statistically evaluates all the measures mentioned above and presents accurate reports on the efficacy of cosmetic products for controlling oiliness and sebum formation. view less | ||
| Anti-wrinkle Clinical Tests | International Research Services, Inc. (IRSI) | IRSI performs instrumental measurements to evaluate the efficacy of cosmetic products on the wrinkles and depth of the expression lines, analyzing standardized digital photographs in some areas of the face (area around the eyes, crow's feet, forehead, etc...view more IRSI performs instrumental measurements to evaluate the efficacy of cosmetic products on the wrinkles and depth of the expression lines, analyzing standardized digital photographs in some areas of the face (area around the eyes, crow's feet, forehead, etc.). We can evaluate the effect of cosmetic products on wrinkles and support the following claims: dermatologically tested, clinically proved, anti-aging/anti-wrinkles/reduces the appearance of wrinkles, analysis of skin relief and wrinkles/fine lines of expression, and self-assessment questionnaires. The results obtained by the tests carried out at IRSI are reliable and can be used to do strategic marketing and also to bring safe and efficacy products to consumers. view less | ||
| Antiacne Clinical Trials | International Research Services, Inc. (IRSI) | OTC drugs products should undergo clinical trials of acnegenicity to evaluate the efficacy of products in the treatment of acne lesions or evaluate the acnegenic potential of the products. The expert's assessment and/or instrumental analysis reveals imp...view more OTC drugs products should undergo clinical trials of acnegenicity to evaluate the efficacy of products in the treatment of acne lesions or evaluate the acnegenic potential of the products. The expert's assessment and/or instrumental analysis reveals important statements of support: dermatologically tested, clinically proved, antiacne, minimize the appearance of pores, oil control/reduce skin greasiness/sebum control/for acne-prone skin, helps remove dirt and dead skin cells, pH balancing, hydration, sustainably strengthens skin barrier function/helps to increase skin self-defense, and reduce inflammation. Our team of experts statistically evaluates all the measures listed above to support OTC drug product manufacturers in claims evidence and to market potentially safe and effective skincare products. view less | ||
| Before & After Photos | International Research Services, Inc. (IRSI) | In 2020 we announced an innovative partnership with Media Lab Science. Founded by beauty expert Ameann DeJohn, Media Lab Science is a dream team of beauty, science and media in one comprehensive space. Designed to bridge the gap between consumer perceptio...view more In 2020 we announced an innovative partnership with Media Lab Science. Founded by beauty expert Ameann DeJohn, Media Lab Science is a dream team of beauty, science and media in one comprehensive space. Designed to bridge the gap between consumer perception testing, clinical testing and social and digital media content, Media Lab Science has the unique ability to provide video testimonials, before and after photos, efficacy claims, social media content, clinical testing and expert grading, all in one place. view less | ||
| Centex® | Buhler Grinding & Dispersing Technologies | Horizontal full volume agitated bead mill with innovative combination of functional elements. Ideal for pass operation, in many cases highly suitable for economic recirculation mode. Conveying EcoMizer™-discs guarantee highest energy efficiency. |  |
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| Compatibility Safety Test | International Research Services, Inc. (IRSI) | For the free marketing of personal care, cosmetics, sanitizing and health/correlated products, clinical trials might be necessary, in order to assure the in use safety. Since the products come in contact with the skin, nails, hair, teeth and mucous membra...view more For the free marketing of personal care, cosmetics, sanitizing and health/correlated products, clinical trials might be necessary, in order to assure the in use safety. Since the products come in contact with the skin, nails, hair, teeth and mucous membranes such as gums and intimate area, these products might cause clinical signs, discomfort sensations or even systemic effects when any ingredients of the formula enters the circulatory blood flow, regardless of the application route. The tests include compatibility, potential irritation, clinical testing, safety testing, photoallergy, phototoxicity, primary irritation, HRIPT, cumulative irritation, patch test, and Human Repeat Insult Patch Test. view less | ||
| Consulting | Buhler Grinding & Dispersing Technologies | Act today to ensure a successful tomorrow: Buhler consulting services give you a decisive competitive edge for the future. For more information about this service, please utilize the "Sales & Technical Support" request link above. | ||
| Fully Hydraulic Three-Roll Mills SDX, SDW, SDY, SDV(E) | Buhler Grinding & Dispersing Technologies | Fully hydraulic three-roll mills can be used for many different applications. They are most suitable for a wide range of medium to high viscosity products, e.g. all kinds of printing inks, artists’ colours, industrial and decorative paints, toners, coatin...view more Fully hydraulic three-roll mills can be used for many different applications. They are most suitable for a wide range of medium to high viscosity products, e.g. all kinds of printing inks, artists’ colours, industrial and decorative paints, toners, coating masses and lubricants, but also for materials for the electronics and cosmetics industries. Three-roll mills are designed for meeting highest quality demands and at the same time enable convenient, easy operation and quick cleaning. view less |  |
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| Image Analysis | International Research Services, Inc. (IRSI) | Image analysis for brightness, matte effect, pores, dark spots, skin homogeneity, porphyrins, wrinkles, eyeshadow/lipstick durability, dark circles under eyes,facial contour, droopy eyelid, lip volume, lip moisturization, lip texture, erythema/irritation,...view more Image analysis for brightness, matte effect, pores, dark spots, skin homogeneity, porphyrins, wrinkles, eyeshadow/lipstick durability, dark circles under eyes,facial contour, droopy eyelid, lip volume, lip moisturization, lip texture, erythema/irritation, acne, pollution, hair, and eyelashes/mask. view less | ||
| IRSI Hair Testing | International Research Services, Inc. (IRSI) | The methodologies are divided into two areas: Clinical Efficacy and Hair Metrology. Clinical Efficacy aims to answer problems related to anomalies of the scalp that alter the healthy aspect of the hair and the quality of life of the people with these an...view more The methodologies are divided into two areas: Clinical Efficacy and Hair Metrology. Clinical Efficacy aims to answer problems related to anomalies of the scalp that alter the healthy aspect of the hair and the quality of life of the people with these anomalies. In this area, the increase or reduction of sebum and oiliness are tested, as well as the appearance or decrease of dandruff caused by the factors mentioned above and the growth and strengthening of the bulb and the hair on subjects with the most diverse types of hair in our extensive subjects’ database. The clinical efficacy area also has a monitored collection of hair swatches for specific studies. Hair Metrology is directed, mainly, to proving the efficacy of cosmetic products in hair swatches acquired from certified suppliers and following a strict ethics code. We do not buy hair from suspect sources of smuggling; we always certify that the hair was donated voluntarily and no damage or trauma was caused to the donor. All the purchased hair goes through a quality control process before being used in tests. In the end, we provide performance evaluation reports of the most common consumer attributes, such as: softness, shine, frizz and volume control, moisturizing, hair conditioning, strength, oil reduction, hydration, breakage reduction, hair loss, anti-dandruff, hair nutrition, repair, heat protection, color maintenance, split ends prevention, curly hair motion, and curl retention. view less | ||
| IRSI Patch Test | International Research Services, Inc. (IRSI) | Evaluating the occurrence of allergic or irritative responses by contacting products with the skin in maximized protocols is an excellent way to assess the safety of topical products. The tests include compatibility, potential irritation, clinical testing...view more Evaluating the occurrence of allergic or irritative responses by contacting products with the skin in maximized protocols is an excellent way to assess the safety of topical products. The tests include compatibility, potential irritation, clinical testing, safety testing, photoallergy, phototoxicity, primary irritation, HRIPT, cumulative irritation, patch test, Human Repeat Insult Patch Test, non-comedogenic, non-acnegenic, and hypoallergenic. view less | ||
| IRSI SPF Test | International Research Services, Inc. (IRSI) | Specialized in dermatological efficacy and safety tests, IRSI is a leader in the use and analysis of instrumental biophysics on the effects of products on human skin. The science and technology applied by IRSI in dermatological assessments offer efficacy ...view more Specialized in dermatological efficacy and safety tests, IRSI is a leader in the use and analysis of instrumental biophysics on the effects of products on human skin. The science and technology applied by IRSI in dermatological assessments offer efficacy and quality in safety tests, transmitting reliable results for a vast array of medicines, cosmetics and dermo-cosmetics. Photoprotection tests offered by IRSI include: Static SPF (FDA and ISO 24444), Broad Spectrum (FDA), UVA Protection PPD & In Vitro (ISO 24442 AND ISO 24443), Water Resistance (FDA and COLIPA), and UV Protection of Fabrics (AS/NZS 4399). view less | ||
| IRSI Use Test | International Research Services, Inc. (IRSI) | The IRSI Use Test is a method to evaluate the performance of products. This type of test can also provide information on consumer behaviors to design an intuitive product (easy and practical) in consumers' lives. | ||
| IRSI Use Test | International Research Services, Inc. (IRSI) | The use of cosmetics is a common practice and has increased in recent years. As a result, concerns about the safety and efficacy of products on a wide range of skin types have also increased, from a baby's delicate skin to mature skin with other specific ...view more The use of cosmetics is a common practice and has increased in recent years. As a result, concerns about the safety and efficacy of products on a wide range of skin types have also increased, from a baby's delicate skin to mature skin with other specific care needs. The IRSI Use Test assesses the real conditions of use and acceptance of topical products through the non-occurrence of allergies and irritability, in addition to proof of claims involving one or more medical specialties in the studies. The tests include safety testing, efficacy testing, use test, non-acnegenic, non-comedogenic, and sensitive skin. view less | ||
| K-Series | Buhler Grinding & Dispersing Technologies | The K series is suitable for a wide range of products from low to very high viscosities.The mill is available in sizes ranging from laboratory to large-production mill and is ideal for scale-up. The core piece is a conical agitator with centrifugal relief...view more The K series is suitable for a wide range of products from low to very high viscosities.The mill is available in sizes ranging from laboratory to large-production mill and is ideal for scale-up. The core piece is a conical agitator with centrifugal relief of the gap separation and intensive stator and rotor cooling. Optional special materials enable contamination-free processes. view less |  |
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| Maintenance | Buhler Grinding & Dispersing Technologies | Even the most robust and reliable machinery and equipment needs regular maintenance. Buhler offers a proven maintenance service for all makes, tailored to your needs. For more information about this service, please utilize the "Sales & Technical Support"...view more Even the most robust and reliable machinery and equipment needs regular maintenance. Buhler offers a proven maintenance service for all makes, tailored to your needs. For more information about this service, please utilize the "Sales & Technical Support" request link above. view less | ||
| Manufacturing & Logistics | Buhler Grinding & Dispersing Technologies | Buhler Manufacturing & Logistics is an independent division of Buhler which operates as an autonomous organization in the marketplace. It supplies competitive assemblies for machines and plants to outside customers and Buhler business units worldwide. It ...view more Buhler Manufacturing & Logistics is an independent division of Buhler which operates as an autonomous organization in the marketplace. It supplies competitive assemblies for machines and plants to outside customers and Buhler business units worldwide. It generates sales revenue (turnover) of about CHF 400 million annually and has a global payroll of 1700. For more information about this service, please utilize the "Sales & Technical Support" request link above. view less | ||
| MicroMedia® | Buhler Grinding & Dispersing Technologies | Small volume annular agitated bead mill with variable power density from 0.1 to 4 kW/l. Designed for reliable use of micro-beads. The beads are concentrated in eddied outer ring layer through which the product flows axially. The MicroMedia® excels by an i...view more Small volume annular agitated bead mill with variable power density from 0.1 to 4 kW/l. Designed for reliable use of micro-beads. The beads are concentrated in eddied outer ring layer through which the product flows axially. The MicroMedia® excels by an intense cooling at the outer stator and in the annular discharge duct between inner rotor and inner stator. view less |  |
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| Prove the Efficacy of Your Product for Nails | International Research Services, Inc. (IRSI) | Clinical tests performed use techniques that reproduce images of hands and nails. Consumer opinion is considered during treatment. Applied techniques evaluate nail shine, overall appearance, texture and smoothness, and color (polish color intensity). | ||
| Repairs | Buhler Grinding & Dispersing Technologies | Machinery outages and production downtime – even when the worst happens, you can rely on the comprehensive support offered by the Buhler service team. You can trust us to provide spare parts and repair services, quickly and anywhere in the world. For more...view more Machinery outages and production downtime – even when the worst happens, you can rely on the comprehensive support offered by the Buhler service team. You can trust us to provide spare parts and repair services, quickly and anywhere in the world. For more information about this service, please utilize the "Sales & Technical Support" request link above. view less | ||
| Retrofit & Reconditioning | Buhler Grinding & Dispersing Technologies | Buying a new machine isn’t always the best solution. Instead, consider updating your existing equipment to the latest specifications. We will be happy to show you just how easy this is. For more information about this service, please utilize the "Sales & ...view more Buying a new machine isn’t always the best solution. Instead, consider updating your existing equipment to the latest specifications. We will be happy to show you just how easy this is. For more information about this service, please utilize the "Sales & Technical Support" request link above. view less | ||
| ROAT - Repeated Open Application Test | International Research Services, Inc. (IRSI) | Aiming to guarantee the least risk to human health possible, studies in safety and maximized conditions (Compatibility Studies) and in Use Conditions (Acceptance Study) were developed. As an alternative in the confirmation of Compatibility in Patch Test, ...view more Aiming to guarantee the least risk to human health possible, studies in safety and maximized conditions (Compatibility Studies) and in Use Conditions (Acceptance Study) were developed. As an alternative in the confirmation of Compatibility in Patch Test, it is possible to use an open application method (open test), known worldwide as ROAT - Repeated Open Application Test. The tests include clinical testing, safety testing, HRIPT, potential irritation, ROAT, Repeated Open Application Test, and Use Test. view less | ||
| Spare Parts | Buhler Grinding & Dispersing Technologies | Only Buhler original parts meet Buhler’s high quality standards. Our precision-manufactured spare parts maintain the value of your machinery, extend its life cycle – and ensure that the valuable product warranty remains valid. For more information about t...view more Only Buhler original parts meet Buhler’s high quality standards. Our precision-manufactured spare parts maintain the value of your machinery, extend its life cycle – and ensure that the valuable product warranty remains valid. For more information about this service, please utilize the "Sales & Technical Support" request link above. view less | ||
| SuperFlow® | Buhler Grinding & Dispersing Technologies | Small volume annular agitated bead mill with axial product flow featuring a power density up to 4 kW/l. The energy introduction is accomplished by turbulent eddying of beads of 0.3–1.5 mm via tightly overlapping pegs. Slim shaped process areas set-up in s...view more Small volume annular agitated bead mill with axial product flow featuring a power density up to 4 kW/l. The energy introduction is accomplished by turbulent eddying of beads of 0.3–1.5 mm via tightly overlapping pegs. Slim shaped process areas set-up in series and internal bead circulation with centrifugal separation at the upper end of the inner process area are unique features of the SuperFlow®. view less |  |
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| Testing for OTC's | International Research Services, Inc. (IRSI) | Sample size and FDA Monograph knowledge are both important factors when choosing a CRO for studies. Both of these are ingrained in IRSI and Allergisa. | ||
| Training & Courses | Buhler Grinding & Dispersing Technologies | Technology is much easier to copy than knowledge, experience, and values. By permanently continuing your education and training, you will remain fit to meet the challenges as they change and you can utilize the potential of your Buhler plant to the full. ...view more Technology is much easier to copy than knowledge, experience, and values. By permanently continuing your education and training, you will remain fit to meet the challenges as they change and you can utilize the potential of your Buhler plant to the full. For more information about this service, please utilize the "Sales & Technical Support" request link above. view less | ||
| Trias® | Buhler Grinding & Dispersing Technologies | Reliability, high raw material yield and gentle dispersion of contamination- and temperature-sensitive products are key properties of the new Buhler three-roll mill. Different roll materials and concepts permit clean room production according to internati...view more Reliability, high raw material yield and gentle dispersion of contamination- and temperature-sensitive products are key properties of the new Buhler three-roll mill. Different roll materials and concepts permit clean room production according to international standards. The camberless VIVA™ roll technology guarantees even product quality independent of the roll pressure. view less |  |
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| Wet Grinding & Dispersing | Buhler Grinding & Dispersing Technologies | In all industries where wet grinding and dispersion are key processes – printing inks, coatings, electronic materials or fine chemicals – Buhler demonstrates a comprehensive know-how and the ability to deliver its customers tailor-made systems for complex...view more In all industries where wet grinding and dispersion are key processes – printing inks, coatings, electronic materials or fine chemicals – Buhler demonstrates a comprehensive know-how and the ability to deliver its customers tailor-made systems for complex processes. As a global technology partner for process engineering, Buhler offers you not only state-of-the-art machines, but also complete solutions for the manufacture of highly advanced materials. view less | ||
| Clean Beauty: The Trend that Came to Stay | International Research Services, Inc. (IRSI) | The #cleanbeauty emerged as a movement aimed at the use of products with non-toxic and effective ingredients for the skin, without harming the environment. It is not necessarily a natural or organic product, but it is safe to use. IRSI has a clinical l...view more The #cleanbeauty emerged as a movement aimed at the use of products with non-toxic and effective ingredients for the skin, without harming the environment. It is not necessarily a natural or organic product, but it is safe to use. IRSI has a clinical laboratory to test the efficacy of cosmetic products, with state-of-the-art equipment, and a team of experts trained to evaluate the efficacy of products considered clean beauty. Being a clean beauty means being careful, attentive and be responsible for the consumer and the environment. IRSI is prepared to contribute to the beauty brands in proving the claims and relationship of brands with the final consumer. view less | ||
| Evidence for the Use of Nutritional Supplements in Skin Care. Does the Science Meet the Demand? | International Research Services, Inc. (IRSI) | Food and cosmetic industries are developing new products and strategies to take advantage of the relationship between nutrient consumption and skin health. Consequently, the use of food ingredients and supplements that claim to reduce the risk of skin dis...view more Food and cosmetic industries are developing new products and strategies to take advantage of the relationship between nutrient consumption and skin health. Consequently, the use of food ingredients and supplements that claim to reduce the risk of skin disorders or alleviate skin ageing is increasing. view less | ||
| How to Know Which Cosmetics are Really Effective? | International Research Services, Inc. (IRSI) | n the cosmetics market, several products prevent the formation and clogging of pores, but how do you know if these products really are effective? | ||
| Importance of Photoprotection and Claims Supported in SPF Studies | International Research Services, Inc. (IRSI) | Due to varying regulations between different countries, it is important to define product registration locations and choose reliable and qualified institutes to carry out the most appropriate clinical studies in accordance with the desired claims and loca...view more Due to varying regulations between different countries, it is important to define product registration locations and choose reliable and qualified institutes to carry out the most appropriate clinical studies in accordance with the desired claims and local regulations. The results of studies carried out by IRSI are reliable and contribute to the support of claims and the development of strategic sunscreen marketing. view less | ||
| IRSI Has Been Working to Ensure the Safety of Products Against Benzene | International Research Services, Inc. (IRSI) | After recent researches detected the presence of chemical benzene (carcinogenic substance found in the burning of carbon and oil) in various sunscreen products commercialized in the USA, IRSI together with Allergisa, a business of ALS, reinforces the atte...view more After recent researches detected the presence of chemical benzene (carcinogenic substance found in the burning of carbon and oil) in various sunscreen products commercialized in the USA, IRSI together with Allergisa, a business of ALS, reinforces the attention to control and safety against undue se of this substance in tested products that reach the consumers. view less | ||
| IRSI Testing Process: Meet the Advantages | International Research Services, Inc. (IRSI) | IRSI is a key partner for clinical trials, as we offer various services, facilitating the sponsor's work on studies, product launches, and brand success. Among the clinical trials, we highlight: HRIPT, Primary Irritation Test, Cumulative Irritation Test, ...view more IRSI is a key partner for clinical trials, as we offer various services, facilitating the sponsor's work on studies, product launches, and brand success. Among the clinical trials, we highlight: HRIPT, Primary Irritation Test, Cumulative Irritation Test, Acnegenicity, Comedogenicity, Sensitive Skin, Safety in Use, Ophthalmological Tests, SPF Test, Efficacy Claim Support, Clinical Assessment, Self Assessment, Before and After Photos, Image Analysis, and Hair Test. view less | ||
| Makeup, Far Beyond Color | International Research Services, Inc. (IRSI) | The demand for multi-benefit products that last has fueled innovation in the color cosmetic sector. IRSI has responded by developing robust testing protocols to meet this market need to prove the safety and efficacy of these innovative products. At IRS...view more The demand for multi-benefit products that last has fueled innovation in the color cosmetic sector. IRSI has responded by developing robust testing protocols to meet this market need to prove the safety and efficacy of these innovative products. At IRSI we can support your color cosmetics launch, substantiating wear claims like: long-wear, all day coverage, water proof, and smudge proof. view less | ||
| Skin Hydration and Firmness | International Research Services, Inc. (IRSI) | Skin hydration is an important condition for the maintenance of a proper skin barrier function leading to a healthy appearance. Moisturizers and hydrators both address the importance of making sure the skin is getting all the water it needs to fight dryne...view more Skin hydration is an important condition for the maintenance of a proper skin barrier function leading to a healthy appearance. Moisturizers and hydrators both address the importance of making sure the skin is getting all the water it needs to fight dryness and dehydration, premature signs of aging, and environmental damage. Nevertheless, the difference lies mostly in how they go about achieving these results. view less | ||
| The Key Role CRO in Clinical Research | International Research Services, Inc. (IRSI) | CRO - Contract Research Organization - is a unique scientific research company contracted to conduct clinical trials in the cosmetic, pharmaceutical and medical device market, facilitating the life cycle of products from conception to approval for commerc...view more CRO - Contract Research Organization - is a unique scientific research company contracted to conduct clinical trials in the cosmetic, pharmaceutical and medical device market, facilitating the life cycle of products from conception to approval for commercialization. It is an essential role of the CRO to help launch safe and effective products for consumers, who are increasingly demanding and concerned about health and well-being. view less | ||
| Understand the Importance of Testing Your Products | International Research Services, Inc. (IRSI) | Cosmetic and pharmaceutical products that reach consumers go through several evaluations to avoid the occurrence of unwanted effects, such as allergy and irritation. Product testing should be done by manufacturerers to offer a safe product to consumers, f...view more Cosmetic and pharmaceutical products that reach consumers go through several evaluations to avoid the occurrence of unwanted effects, such as allergy and irritation. Product testing should be done by manufacturerers to offer a safe product to consumers, following guidelines recommended by regulatory agencies, such as the FDA, or by country-specific legislation. view less |
