COUPERINE from Phenbiox is a mix of bioliquified rocket salad leaves and prickly pear flowers able to help very sensitive skin to be less prone to develop couperose and to lessen it when already present. Rocket salad contains isothiocyanates able to boost the synthesis of the tripeptide glutathione, the only endogenous antioxidant of our body. Glutathione participates directly in the neutralization of free radicals and maintains vitamins C and E in their active forms. Glutathione plays a prominent role in DNA protection, in the detoxification processes and in contrasting the inflammatory processes often related to radical presence. Prickly pear flowers have been used in traditional medicine and in recent years the antioxidants and polysaccharides contained in it have been proven to be able to protect both large and small blood vessels from oxidative damage. They can also mitigate micro-vessel damage and maintain micro-capillary integrity by stabilizing capillary walls. The combination of endogenous and exogenous antioxidants and protective molecules, as well as the soothing and conditioning effects of the mix of molecules contained in COUPERINE allow to effectively reduce couperose from the first week of application.